Solitary fibrous tumor of the adrenal gland – its biological behavior and report of a new case

Abstract Introduction A solitary fibrous tumor (SFT) is an uncommon neoplasm of mesenchymal and probably fibroblastic origin, occurring mainly in the extremities, pleura. However, a primary involvement endocrine organs rare even exceptional when found adrenal gland. Hereby, we describe 10th report SFT. Case presentation 77-year old man was diagnosed with lesion right gland during urologic indicated computed tomography (CT). No symptoms laboratory anomalies were reported indicating any activity. Follow up CT-scans showed progressive growth nodule for which patient underwent laparoscopic adrenalectomy. Histological examination hypercellular spindle cell elongated nuclei low mitotic index. The vessels arranged hemangiopericytoma-like pattern slight sclerosing appearance. Immunohistochemistry positive staining neoplastic cells STAT6, CD-34 Bcl-2. Translocation analysis using RT-PCR no NAB2-STAT6 fusion. specimen confirmed as variant Discussion SFT Differential diagnosis can be broad because defined pathognomonic morphological characteristics. gene fusions are considered molecular hallmark SFTs. Therefore, STAT6 immunohistochemistry valuable diagnostic tool differentiating between histologic mimics. After diagnosing SFT, its biological behavior difficult to predict. SFTs mostly benign tumors. Nonetheless, histological benign-appearing show malignant clinical characteristics impeding assessment proper follow up. malignancy has not been previously case report.